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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: FREM3 All Species: 6.67
Human Site: T257 Identified Species: 20.95
UniProt: P0C091 Number Species: 7
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P0C091 NP_001161707 2135 237764 T257 V R Y Q H T A T S S P N R D Y
Chimpanzee Pan troglodytes XP_517461 2289 255014 T407 V R Y Q H T A T S S P N R D Y
Rhesus Macaque Macaca mulatta XP_001092507 2276 253244 A394 V R Y Q H T A A S S P N R D Y
Dog Lupus familis XP_543127 3169 350410 G269 R Y R H T A P G R S P N R D W
Cat Felis silvestris
Mouse Mus musculus Q5H8B9 2123 234980 P249 R Y Q H T T T P S S P S R D Y
Rat Rattus norvegicus Q00657 2326 251891 F242 S Q Q A P L A F Q A G D K R G
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_417087 3168 351300 T254 L G L R Y R H T A A G S S P N
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_796581 2335 258813 P306 L V F F I S Q P F G P D E G Y
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 92.2 88.7 39.3 N.A. 68 20 N.A. N.A. 39.7 N.A. N.A. N.A. N.A. N.A. N.A. 27.9
Protein Similarity: 100 92.6 90.9 49.8 N.A. 80.1 35.7 N.A. N.A. 50.4 N.A. N.A. N.A. N.A. N.A. N.A. 45.2
P-Site Identity: 100 100 93.3 33.3 N.A. 46.6 6.6 N.A. N.A. 6.6 N.A. N.A. N.A. N.A. N.A. N.A. 13.3
P-Site Similarity: 100 100 93.3 40 N.A. 53.3 33.3 N.A. N.A. 46.6 N.A. N.A. N.A. N.A. N.A. N.A. 40
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 13 0 13 50 13 13 25 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 25 0 63 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 13 0 0 % E
% Phe: 0 0 13 13 0 0 0 13 13 0 0 0 0 0 0 % F
% Gly: 0 13 0 0 0 0 0 13 0 13 25 0 0 13 13 % G
% His: 0 0 0 25 38 0 13 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 13 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 13 0 0 % K
% Leu: 25 0 13 0 0 13 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 50 0 0 13 % N
% Pro: 0 0 0 0 13 0 13 25 0 0 75 0 0 13 0 % P
% Gln: 0 13 25 38 0 0 13 0 13 0 0 0 0 0 0 % Q
% Arg: 25 38 13 13 0 13 0 0 13 0 0 0 63 13 0 % R
% Ser: 13 0 0 0 0 13 0 0 50 63 0 25 13 0 0 % S
% Thr: 0 0 0 0 25 50 13 38 0 0 0 0 0 0 0 % T
% Val: 38 13 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 13 % W
% Tyr: 0 25 38 0 13 0 0 0 0 0 0 0 0 0 63 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _